Professional Publications

NCBP has produced a number of crucial papers, presentations, book chapters and posters on the biology, processing and transplant of stem cells from cord blood. A selective list of such peer-reviewed publications is presented below.

  • + 2019

    CD34+ cell content of 126 341 cord blood units in the US inventory: implications for transplantation and banking.
    J.N. Barker, J. Kempenich, J. Kurtzberg, C.G.Brunstein, C. Delaney, F. Milano, I. Politikos, E.J. Shpall, A. Scaradavou, J. Dehn J. Blood Adv. 2019 23; 3:1267-1271. doi: 10.1182/bloodadvances.2018029157

    Racial disparities in access to HLA-matched unrelated donor transplants: a prospective 1312-patient analysis.
    J.N. Barker, K. Boughan, P.B. Dahi, S.M. Devlin, M.A. Maloy, K. Naputo, C.M. Mazis, E. Davis, M. Nhaissi, D. Wells, C. Cooper, D.M. Ponce, N. Kernan, A. Scaradavou, S.A. Giralt, E.B. Papadopoulos, I. Politikos. Blood Adv. 2019; 3: 939-944. doi: 10.1182/bloodadvances.2018028662.

    Adoptive Immunotherapy with Cord Blood for the Treatment of Refractory Acute Myelogenous Leukemia: Feasibility, Safety, and Preliminary Outcomes.
    U. Gergis, E. Mason Frenet, T. Shore, S. Mayer, A. Phillips, J.M. Hsu, G. Roboz, E. Ritchie, J. Scandura, S. Lee, P. Desai, M. Samuel, J. Ball, A. Blanco, C. Romeo, M.S. Albano, L. Dobrila, A. Scaradavou , K. van Besien. BBMT 2019; 25: 466-473.

  • + 2018

    Impact of Delayed Umbilical Cord Clamping on Public Cord Blood Donations: Can We Help Future Patients and Benefit Infant Donors?
    Ciubotariu R., Scaradavou A., Ciubotariu I., Tarnawski M., Lloyd S., Albano M., Dobrila L., Rubinstein P., Grunebaum A. Transfusion. DOI: 10.1111/trf.14574 February 2018

  • + 2017

    Cytomegalovirus viral load in cord blood and impact of congenital infection on markers of hematopoietic progenitor cell potency.
    M. Susana Albano, Rodica Ciubotariu, Ludy Dobrila, Michal Tarnawski, Margely DeLeon, Chiseko Watanabe, Siddarth Krishnan, Andromachi Scaradavou and Pablo Rubinstein. Transfusion. 2017 Nov;57(11):2768-2774. doi: 10.1111/trf.14257. Epub 2017 Jul 31

    When selecting a cord blood unit from a firstborn donor verify that the patient shares an Ag with the unit that is foreign to the mother of the donor.
    J.J. van Rood, A. Brand, A. Scaradavou, F.H. Claas, M. Oudshoorn, C.E. Stevens. BMT  2017; 52:1039-1040. 

    Best Practices in Processing and Storage for Hematopoietic Cell Transplantation
    Springer 2017; Editors: J. Schwartz, B. Shaz. A. Scaradavou. Cord Blood Graft Assessment and Selection Criteria for Transplantation; (in press).

    Unrelated cord blood transplantation for non-malignant diseases: every HLA allele counts.
    Lancet Haematol. 2017 (invited paper A.Scaradavou); 4(7):e307-e308.

  • + 2015

    Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.
    K.K. Ballen, B.R. Logan, M.J. Laughlin, W. He, D.R. Ambruso, S.E. Armitage, R.L. Beddard, D. Bhatla, W.Y. Hwang, J.E. Kiss, G. Koegler, J. Kurtzberg, A. Nagler, D. Oh, L.D. Petz, T.H. Price, R.R. Quinones, V. Ratanatharathorn, J.D. Rizzo, K. Sazama, A. Scaradavou, M.W. Schuster, L.S. Sender, E.J. Shpall, S.R. Spellman, M. Sutton, L.A. Weitekamp,J.R.  Wingard, M. Eapen. BBMT 2015; 21: 688-695.

    How we handled the dextran shortage: an alternative washing or dilution solution for cord blood infusions.
    Reich-Slotky R, Bachegowda LS, Ancharski M, Mendeleyeva L, Rubinstein P, Rennert H, Shore T, van Besien K, Cushing M. Transfusion. 2015 Jun;55(6):1147-53. doi: 10.1111/trf.13015. Epub 2015 Feb 5.

    Banking or Bankrupting: Strategies for Sustaining the Economic Future of Public Cord Blood Banks.
    Magalon J, Maiers M, Kurtzberg J, Navarrete C, Rubinstein P, Brown C, Schramm C, Larghero J, Katsahian S, Chabannon C, Picard C, Platz A, Schmidt A, Katz G. PLoS ONE 2015. Dec 1;10(12): e0143440.

    Cord Blood Stem Cells Medicine
    Academic Press 2015: Editors: C. Stavropoulos-Giokas, D. Charron, C. Navarrete. A. Scaradavou: Cord Blood Unit Selection for Unrelated Transplantation; 211-228.

  • + 2014

    Noninherited maternal antigens identify acceptable HLA mismatches: benefit to patients and cost-effectiveness for cord blood banks.
    Van der Zanden HG, Van Rood JJ, Oudshoorn M, Bakker JN, Melis A, Brand A, Scaradavou A, Rubinstein P. Biol Blood Marrow Transplant. 2014 Nov;20(11):1791-5. doi: 10.1016/j.bbmt.2014.07.011. Epub 2014 Jul 18.

    Umbilical Cord Blood Banking and Transplantation
    Jumana Press 2014; Editor: K. Ballen. A. Scaradavou: Maternal HLA typing and Cord Blood Unit choice; 49-58.

  • + 2013

    Double unit grafts successfully extend the application of umbilical cord blood transplantation on adults with acute leukemia.
    A. Scaradavou, C.G. Brunstein, M. Eapen, J. Le-Rademacher, J.N. Barker, N. Chao, C. Cutler, C. Delaney, F. Kan, L. Isola, C. Kanares, M.J. Laughlin, J.E. Wagner, E.J. Shpall. Blood 2013; 121: 752-58.

    Transfusion Medicine and Hemostasis: Clinical and laboratory aspects.
    Elsevier Second edition 2013. A. Scaradavou: HLA Antigens; 191-199.

  • + 2012

    A perspective on the selection of unrelated donors and cord blood units for transplantation.
    Spellman SR, Eapen M, Logan BR, Mueller C, Rubinstein P, Setterholm MI, Woolfrey AE, Horowitz MM, Confer DL, Hurley CK. Blood. 2012 Jul 12; 120(2):259-65. Epub 2012 May 17.

    Indirect evidence that maternal microchimerism in cord blood mediates a graft-versus-leukemia effect in cord blood transplantation.
    J.J. van Rood, A. Scaradavou, C.E. Stevens. Proc Natl Acad Sci USA 2012; 109: 2509-2514.

    HLA-mismatched, noninherited maternal antigen-matched unrelated cord blood transplantations have superior survival: how HLA typing the cord blood donor’s mother can move the field forward.
    (Invited paper A. Scaradavou) BBMT 2012; 18: 1773-1775

  • + 2011

    Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.
    Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, Defor T, Levine BL, June CH, Rubinstein P, McGlave PB, Blazar BR, Wagner JE. Blood. 2011 Jan 20; 117(3):1061-70. Epub 2010 Oct 15. 

    Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries.
    Cohen YC, Scaradavou A, Stevens CE, Rubinstein P, Gluckman E, Rocha V, Horowitz MM, Eapen M, Nagler A, Shpall EJ, Laughlin MJ, Daniely Y, Pacheco D, Barishev R, Olmer L, Freedman LS. Bone Marrow Transplant. 2011 Jan; 46(1):70-6. Epub 2010 May 3.

    Guidelines for the development and validation of new potency assays for the evaluation of umbilical cord blood
    Spellman S, Hurley CK, Brady C, Phillips-Johnson L, Chow R, Laughlin M, McMannis J, Reems JA, Regan D, Rubinstein P, Kurtzberg J. Cytotherapy. 2011 Aug; 13(7):848-55. Epub 2011 Mar 30.

    Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: Reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue.
    Zhang X, Hirai M, Cantero S, Ciubotariu R, Dobrila L, Hirsh A, Igura K, Satoh H, Yokomi I, Nishimura T, Yamaguchi S, Yoshimura K, Rubinstein P, Takahashi TA. J Cell Biochem. 112(4):1206-18, 2011.

    HLA mismatch direction in cord blood transplantation: impact on outcome and implications for cord blood unit selection.
    C.E. Stevens, C. Carrier, C. Carpenter, D. Sung, A. Scaradavou. Blood 2011; 118: 3969-3978.

    How I treat: the selection and acquisition of unrelated cord blood grafts.
    J.N. Barker, C. Byam, A. Scaradavou. Blood 2011;117: 2332-2339.

    Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts.
    S. Avery, W. Shi, M. Lubin, A.M. Gonzales, G. Heller, H. Castro-Malaspina, S. Giralt, N.A. Kernan, A. Scaradavou, J.N. Barker. Blood 2011; 117: 3277-3285.

  • + 2010

    Histocompatibility and Immunogenetics in Cord Blood Transplantation.
    Rubinstein P and Hillyer C. Biological Research. 43(3):339-345, 2010.

    Platelet transfusions to HLA-immunized recipients: how to be or not to be matched.
    Rubinstein P. Transfusion. 50(11):2292-4, 2010.

    Unrelated Umbilical Cord Blood Unit Selection.
    A. Scaradavou. Seminars in Hematology 2010; 47:13-21.

    Combined Effect of Total Nucleated Cell Dose and HLA-Match on Transplant Outcome in 1,061 Cord Blood Recipients with Hematological Malignancies
    J.N. Barker, A. Scaradavou, C.E. Stevens. Blood 2010; 115: 1843-1849.

    Unrelated Umbilical Cord Blood Unit Selection.
    Seminars in Hematology 2010 (Invited paper A. Scaradavou); 47:13-21.

  • + 2009

    Cord blood banking for clinical transplantation
    P. Rubinstein. Bone Marrow Transplantation 2009; 44: 635-642.

    Re-exposure of cord blood to non-inherited maternal HLA antigens improves transplant outcome in hematological malignancies and might enhance its anti-leukemic effect. 
    J.J. van Rood, C.E. Stevens, J. Schmits, C. Carrier, C. Carpenter, A. Scaradavou. Proceedings of the National Academy of Sciences USA 2009; 106: 19952-19957.

    Cord blood banking: ‘providing cord blood banking for a nation’
    S. Querol, P. Rubinstein, S.G. March, J. Goldman, J.A. Madrigal. British Journal of  Haematology 2009; 147: 227-235.

    Extracellular DNA in cord blood plasma and applications in cord blood banking for sample identification. 
    M.S. Albano, A. Scaradavou, C.E. Stevens, P. Rubinstein. Transfusion 2009; 49: 1685-1691.

  • + 2008

    Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial-antigen presenting cells.
    K.L. Hippen, P. Harker-Murray, S.B. Porter, S.C. Merckel, A. Londer, D.K. Taylor, M. Bina, A. Panoskaltsis-Mortari, P. Rubinstein, N. van Rooijen, T.N. Golovina, M.M. Suhoski, J.S. Miller, J.E. Wagner, C.H. June, J.L. Riley, B.R. Blazar. Blood 2008; 112:2847-2857.

  • + 2007

    Combined Neonatal Blood Transplants in a Parent-to-F1 Mouse Model: Improved Survival Rates and Stable Long-term Engraftment.
    A. Scaradavou, D. Sung, P. Rubinstein. American Journal of  Hematology 2007; 82: 961-969.

    Umbilical cord blood collection: do patients really understand?
    Fox NS, Stevens C, Ciubotariu R, Rubinstein P, McCullough LB, Chervenak FA. Journal of Perinatal Medicine 2007, 35: 314-321.

    Comparison of Outcomes after Transplantation of Unrelated Donor Umbilical Cord Blood and Bone Marrow in Children with Acute Leukemia.
    M. Eapen, P. Rubinstein, M-J. Zhang, C. Stevens, J. Kurtzberg, A. Scaradavou, F.R. Loberiza, R.E. Champlin, J.P. Klein, M.M. Horowitz, J.E. Wagner. The Lancet 2007; 369 (9577): 1947-54.

  • + 2006

    Umbilical Cord Blood transplantation and Cytomegalovirus: Post-transplant infection and donor screening.
    M.S. Albano, P.E. Taylor, R.F. Pass, A. Scaradavou, R. Ciubotariu, C. Carrier, L. Dobrila, P. Rubinstein, C.E. Stevens. Blood 2006; 108:4275-82.

    Why cord blood?
    P. Rubinstein. Human Immunology 2006; 67: 398-404.

    Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantation for acute leukemia in children younger than 18 months.
    M. Eapen, P. Rubinstein, M.J. Zhang, B.M. Camita, C. Stevens, M.S. Cairo, S.M. Davies, J.J. Doyle, J. Kurtzberg, M.A. Pulsipher, J.J. Ortega, A. Scaradavou, M.M. Horowitz, J.E. Wagner. Journal of Clinical Oncology 2006; 24(1): 145-51.

  • + 2005

    Immunophenotype of hematopoietic stem cells from placental/umbilical cord blood after culture.
    Pranke P, Hendrikx J, Debnath C, Alespeiti G, Rubinstein P, Nardi N, Visser, J. Braz, Journal of Medical and Biological Research 2005; 38: 1775-1789.

  • + 2004

    Outcomes after transplantation of cord blood or bone marrow from unrelated donors for adults with leukemia.
    M.J. Laughlin, M. Eapen, P. Rubinstein, J.E. Wagner, M-J Zhang, R.E. Champlin, C. Stevens, J.N. Barker, R.P. Gale, H.M. Lazarus, D.I. Marks, J.J. van Rood, A. Scaradavou and M.M. Horowitz. New England Journal of Medicine 2004; 351: 2265-2275.

    Cord-blood transplants from unrelated donors in patients with Hurler's Syndrome.
    Staba SL, Escolar ML, Poe M, Kim Y, Martin PL, Szabolcs P, Allison-Thacker J, Wood S, Wenger PA, Rubinstein P, Hopwood JJ, Krivit W and Kurtzberg, J. New England Journal of Medicine 2004; 350:1960-1969.

  • + 2003

    Obstetric predictors of placental/umbilical cord blood volume for transplantation.
    ones J, Stevens CE, Rubinstein P, Robertazzi RR, Kerr A, and Cabbad MF. American Journal of Obstetrics and Gynecology, 2003; 188(2):503-9.

  • + 2002

    Placental/umbilical cord blood for unrelated bone marrow reconstitution: Relevance of nucleated red blood cells.
    Stevens CE, Gladstone J, Taylor PE, Scaradavou A, Migliaccio AR, Visser J, Dobrila, NL, Carrier C, Cabbad M, Wernet P, Kurtzberg J, and P. Rubinstein, Blood, 2002; 100:2662-2664.

  • + 2001

    Hematopoietic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors.
    Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE, Gerson SL, Lazarus HM, Cairo M, Stevens CE, Rubinstein P, and Kurtzberg J. New England Journal of Medicine 2001; 344:1815-1822.

    Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia.
    Vanderson R, Comish J, Sievers EL, Filipovich A, Locatelli F, Peters C, Remberger M, Michel G, Arcese W, Dallorso S, Tiedmann K, Busca A, Chan KW, Kato S, Ortega J, Vowels M, Zander A, Souillet G, Oakill A, Woolfrey A, Pay AL, Green A, Garnier F, Ionescu I, Wernet P, Sirchia G, Rubinstein P, Chevret S, and Gluckman E. Blood, 2001; 97:2962-2971.

    The New York Blood Center's Placental/Umbilical Cord Blood Program: Experience with a "new" source of hematopoietic stem cells for transplantation
     Rubinstein P, and Stevens CE. Ernst Schering Research Foundation Workshop, 2001; 33:47-70.

  • + 2000

    Graft-versus-leukemia induced complete remission following unrelated umbilical cord blood transplantation for acute leukemia.
    Howrey RP, Martin PL, Driscoll T, Szabolcs P, Kelly T, Shpall EJ, Bearman SI, Slat-Vasquez V, Rubinstein P, Stevens CE, and Kurtzberg J. Bone Marrow Transplantation, 2000; 26:1251-1254.

    Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: Graft progenitor cell content is a better predictor than nucleated cell quantity.
    Migliaccio AR, Adamson JW, Stevens CE, Dobrila LN, Carrier CM, and P. Rubinstein. Blood, 2000; 96:2717-2722.

    The frequency and proliferative potential of megakaryocytic colony-forming cells (Meg-CFC) in cord blood, cytokine-mobilized peripheral blood and bone marrow, and their correlation with total CFC numbers: Implications for the quantitation of Meg-CFC to predict platelet engraftment following cord blood transplantation. vonDrygalski A, Xu G, Constantinescu D, Kashiwakura I, Farley T, Dobrila NL, P. Rubinstein, and Adamson JW. Bone Marrow Transplantation, 2000; 25:1029-1034.

    Placental blood for bone marrow replacement: The New York Blood Center's program and clinical results.
    Rubinstein P, and Stevens CE. Balliere's Best Practice & Research in Clinical Hematology, 2000; 13:565-584.

    Measurements from normal umbilical cord blood of four lysosomal enzymatic activities: A-L-iduronidase (Hurler), galactocerebrosidase (globoid cell leukodystrophy), arylsufatase A (metachromatic leukodystrophy), arylsulfatase B (Maroteaux-Lamy). deGasperi R, Raghavan SS, Gama Sosa MA, Kolodny EH, Carrier CM, Rubinstein P, Peters C, Wagner J, Kurtzberg J, and Krivit W. Bone Marrow Transplantation, 2000; 25:541-544.

    Unrelated placental blood in marrow transplantation.
    Kurtzberg J, Martin P, Chao N, Stevens CE, and Rubinstein P. Stem Cells, 2000; 18:153-154.